It wasn't necessarily the best or biggest joke, but when dude said "Tough break here, bud." right after the former press secretary guy got 'fired' by Selina in the car, I was laughing so long and hard, I didn't hear the dialog for the next couple of scenes. The pitch perfect timing and inflection for that line just totally killed me.
Pretty damn sad this is the last season.
"Sean sparks like John Starks, nah, Sean ball like John Wall" - Rest In Power Forever Sean Price.