The hardest part is the whole legal aspect of it (setting it up and the 501 (c) (3) status).
If you don't have the money, you need to find attorneys that do pro-bono work

In regards to the board, which is part of the setting up process, You need to find people that share the same ideas with you, and are willing to put some work in it. Also the board memeber names bring credentials to your organization, which is extremely important in the fundraisisng part.

That's what I've heard from people who've done this.
Once you have it up, then it's just work