https://www.tsa.gov/travel/security-screening/whatcanibring/items/medical-marijuana

"Accordingly, TSA security officers do not search for marijuana or other illegal drugs, but if any illegal substance is discovered during security screening, TSA will refer the matter to a law enforcement officer."

Opiods can look like any other legit medication, and even if they didn't - they don't care. And that's NOT counting on charter/private, etc flights.