TWD has always killed off main characters in the past and I don't think AMC is afraid to do it. It may not play out exactly as it did in the comics and will get remixed but there should be a major death coming.

IMO, Carol, Darryl, and Glen seem the most likely at this point but who knows.

The death of Denise is a huge loss for Alexandria being that she is the only doctor in the community. Especially at a time like this when they're about to be at war with the Saviors.