She basically defines chemistry with Clooney in Out of Sight but couldn't get a spark going with either Jesus or Wooderson, nor, presumably, with Affleck. I think a lot of chemistry has to do with the character(s)* / director but also who one actor is playing across from. I'm sure Clooney could have chemistry with a pair of tennis shoes, so that's probably why the deficiency elsewhere in her career.



*Her character in U-Turn has plenty going that she is able to bring out well enough.