Gene Therapy = intentionally altering one's DNA/genome in some way to treat disease (eg. gene editing being explored for conditions like hemophilia, leukemia, blindness, etc https://www.mayoclinic.org/tests-procedures/gene-therapy/about/pac-20384619)

The molecular bio behind how mRNA vaccination differ centers on a few things:

1. In eukaryotes (the domain humans belong to) our genomes/DNA are contained within the nuclei of our cells. Each nucleus is then surrounded by a pool of cellular machinery and goo called cytoplasm, which is itself surrounded by a membrane made of a mostly fat (aka lipid) bilayer and embedded proteins. This entire structure and its contents constitute what we call a cell;

2. The mRNA delivered by the covid vaccines is produced by scientists externally, not by our cells (https://en.wikipedia.org/wiki/Messenger_RNA#/media/File:MRNA-interaction.png <--- in this figure consider the vaccine mRNA the mRNA molecule outside the nucleus), so once introduced it ONLY HAS ACCESS TO OUR CYTOPLASM. It can never interfere or interact with our genomes/DNA or the machinery (eg DNA polymerases) specifically responsible for replicating and editing DNA - because these are located exclusively in the nuclei of our cells, not the cytoplasm;

3. A more accurate way to think of the vaccine mRNA is... like a self-destructing text message sent to your immune system (the "m" in mRNA is even shorthand for messenger RNA). Because, unlike DNA, RNA molecules have a super short half-life in vivo (https://www.sciencedaily.com/releases/2017/07/170712201054.htm) and are degraded and eliminated from our system soon after their production/use.

So all the mRNA vaccines do is help the self-destructing message enter our cells (via a fat/lipid nanoparticle) so it can quickly inform relevant cell machinery in our cytoplasm (eg. ribosomes) how to TKO this coronavirus (by producing dummy replicas of its achilles heel, the spike protein, which our immune system can now recognize and create targeted antibodies for - https://medlineplus.gov/genetics/understanding/therapy/mrnavaccines). This is VERY different than use of viral vectors for gene therapy (which, for starters, leverages the machinery of *whole viruses* to infiltrate our cells and CORRECT mutated genetic material, just that scientists have adapted the virus so that it works for us rather than doing its usual infection thing). The mRNA vaccine is sending a self-destructing message ABOUT THE VIRUS (about a specific coronavirus protein) to our immune systems, where as gene therapy uses WHOLE VIRUS machinery to correct a genetic abnormality in the host.

Also - there might be discrepancies with the rest of what you wrote too but since there are no sources I won't fret too much. I do just want to point out that regulation of pharmaceuticals and biologics falls exclusively under the FDA tho. A lot of people lump NIH in there bc they fund so much of the research but that's incorrect.




>This is experimental biological gene therapy immune modulatory
>injection. Injecting ppl with a synthetic sequence of nucleic
>acid has never been done on a large scale in human history.
>RNA trials in mammals have led to odd cancers and autoimmune
>diseases from 6 to 12 months after the injection.
>
>Also, if there is a treatment for a disease, the federal gov't
>cannot approve a vaccination. The NIH (who is involved in
>approving medications) cohold the patent to the vaccine with
>Moderna. There you have the gov't in bed with a private
>company, vending a product that they want to give to everyone.
>Conflict of interest. They don't want a therapy to work,
>because then they can't sell the vaccine.
>
>But this just notes from a curious nigga trying to do a lil
>research.