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Forum nameGeneral Discussion
Topic subjectPfizer's COVID anti-viral drug thread
Topic URLhttp://board.okayplayer.com/okp.php?az=show_topic&forum=4&topic_id=13439076&mesg_id=13439076
13439076, Pfizer's COVID anti-viral drug thread
Posted by handle, Thu Aug-05-21 10:27 AM
I missed the news, but it's entered Phase 2 trials.

If this works then COVID may be manageable. Imagine getting a positive test and taking a pill twice a day for 10 days that suppresses COVID replication so your immune system can take it out easier.

Facui spoke about it here: https://www.csis.org/analysis/conversation-dr-anthony-fauci-antiviral-program-pandemics

Biden's giving $3.2 billion: https://www.niaid.nih.gov/news-events/biden-administration-invest-3-billion-american-rescue-plan-part-covid-19-antiviral


Swipe about pill:
http://fool.com/investing/2021/08/03/this-could-be-pfizers-next-covid-blockbuster-and-i/

Chief scientific officer Mikael Dolsten said that in the phase 1 study, PF-07321332 exceeded the level predicted to inhibit coronavirus viral replication by more than fivefold. Dolsten also stated that the experimental protease inhibitor showed powerful antiviral activity in preclinical testing that could be effective against "all currently known COVID-19 variants."

So far, the experimental antiviral drug appears to have a good safety profile. Dolsten said that there haven't been any safety issues in giving doses of up to 500 milligrams twice per day over a 10-day period.

Based on these encouraging results, Pfizer advanced the oral protease inhibitor into phase 2/3 testing in July. The company will evaluate PF-07321332 in five-day and 10-day treatments for individuals who have been in close contact with someone with COVID-19.

Coming soon?
There shouldn't be a long wait for Pfizer's next potential COVID-19 blockbuster. Assuming the phase 2/3 testing goes well, the company thinks that it will be able to file for U.S. EUA in the fourth quarter of this year.