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Topic subjectThe lead immunologist on the team that developed the mRNA vaccine
Topic URLhttp://board.okayplayer.com/okp.php?az=show_topic&forum=4&topic_id=13437897&mesg_id=13438362
13438362, The lead immunologist on the team that developed the mRNA vaccine
Posted by soulfunk, Wed Jul-28-21 01:58 PM
is Black - Dr. Kizzmekia Corbett. Her research on SARS vaccines was used in her suggesting using mRNA for COVID-19...

https://en.wikipedia.org/wiki/Kizzmekia_Corbett#Development_of_COVID-19_vaccine

Development of COVID-19 vaccine
At the onset of the COVID-19 pandemic, Corbett started working on a vaccine to protect people from coronavirus disease. Recognizing that the virus was similar to severe acute respiratory syndrome coronavirus, Corbett's team utilized previous knowledge of optimal coronavirus S proteins to tackle the novel coronavirus. S proteins form a “crown” on the surface of coronaviruses and are crucial for engagement of host cell receptors and the initiation of membrane fusion in coronavirus disease. This makes them a particularly vulnerable target for coronavirus prophylactics and therapeutics. Based on her previous research, Corbett's team, in collaboration with Jason McLellan and other investigators at The University of Texas at Austin, transplanted stabilizing mutations from SARS-CoV S protein into SARS-CoV-2 spike protein. She was part of the NIH team who helped solve the cryogenic electron microscopy (CryoEM) structure of the SARS-CoV-2 spike protein. Her prior research suggested that messenger RNA (mRNA) encoding S protein could be used to excite the immune response to produce protective antibodies against coronavirus disease 2019.

To manufacture and test the COVID-19 vaccine Corbett's team partnered with Moderna, a biotechnology company, to rapidly enter animal studies. Subsequently, the vaccine entered Phase 1 clinical trial only 66 days after the virus sequence was released. The trial, to be completed in at least 45 people, is a dose escalation study in the form of two injections separated by 28 days. In December 2020, the Institute's Director, Anthony Fauci said: "Kizzy is an African American scientist who is right at the forefront of the development of the vaccine." In the Time's profile, Fauci wrote that Corbett has "been central to the development of the Moderna mRNA vaccine and the Eli Lilly therapeutic monoclonal antibody that were first to enter clinical trials in the U.S." and that "her work will have a substantial impact on ending the worst respiratory-disease pandemic in more than 100 years." Corbett's work afforded her the opportunity to be a part of the National Institutes of Health team that had Donald Trump at the Dale and Betty Bumpers Vaccine Research Center in March 2020. When asked about her involvement with the development of the COVID-19 vaccine, Corbett said, "To be living in this moment where I have the opportunity to work on something that has imminent global importance…it's just a surreal moment for me". Corbett stated she cried when the efficacy results showed the mRNA-1273 Moderna vaccine worked.