Hmmm...I can't really say his BEST line because that would be hard as hell. But this past week I been listening to One Day a lot, and that CD had some pretty tight ones. Also, keep in mind that "Hungry" is probably in my top three favorites. How could it not be with lines like this??
"shit is so banging niggas say its gang-related"
or
"skip ladies this is rip a muthafucka night"
"you need to do more deleting and less saving"

Also
"Inhale imagination and breathe wonder"
"its gonna be some drama you try and sit Com down, this ain't comedy"
"I came through the corra-dor with the aura, Raw chicago mora, scope the horror"
"If you believe in heaven, why is the choice hell?"
"The cops, ya'llknow what they be one, a nigga's life is like a field that they play on"

And I could go on forever, but these are ones I can think of now.

Peace

~~~welcome to my sig~~~

"For if they come for you in the morning, they will be coming for us at night." - James Baldwin

"Ain't nobody perfect, cause ain't nobody free."- Nina Simone

"If you God then save your own, don't mentally enslave your own"- Cee Lo

"Only the strong go crazy; the weak just go along."- Assata Shakur