304986, i've never played custom mode Posted by bearfield, Tue Feb-04-20 03:49 PM
i don't think the mutation unlocks are affected by RNG. my recollection is that you get funneled into the room with a mutation, which happens somewhat naturally within the flow of the game. you might need to make use of the most recent mutation unlock to access the next one
which biomes have you been to? in order to unlock more stuff you need to play and explore. don't worry about the bonus doors. just take your time and pick each biome clean before advancing to the next one and you should be swimming in cells and unlocks
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