I was thinking this while watching Wilder's last fight with Ortiz. If Fury comes back as the Fury he was before he left, he definitely could be Wilder. He's the only person who'd have size advantages AND skill that could neutralize Wilder. What's funny is that Fury posted a video on social media right after that fight, saying that he promised Wilder year ago in a post-fight confrontation that he'd knock him out, and after seeing the fight, he was sure he would lol.
If Wilder won THAT fight by KO, I'd be very surprised... even more surprised than the Ortiz KO.